Tags

    Environmental health and toxicology

    Withgott (author of our Froggie iBook)
    Sixth edition of his text, chapter 14 notes:
    Download file "withgott 14 health-toxicology.pdf"

    apes withgott 6e.14

    See also chapter 17 in the F/R text:

    mod 56 Human Disease

    mod 57 Toxicology and chemical risk

    mod 58 Risk Analysis

    Back to Withgott.....

    BPA-bisphenol-A

    Water bottles, food, baby bottles, tupperware

    Endocrine disruptors: what are they, how do they work?

    BPA is an estrogen analog: https://en.wikipedia.org/wiki/Bisphenol_A

    Hormone mimicry:





    4 Hazards:

    Physical e.g. UV radiation (DNA damage)

    Chemical e.g. drugs, pesticides, venoms, synthetic and natural

    Biological e.g. infectious diseases (vectors)

    Cultural e.g. smoking, COPD, seat belts, hang gliding, swimming with sharks

    Non-infectious diseases: genetics + environmental factors, e.g. cancer, heart disease, obesity

    Infectious diseases (ID): ebola, influenza, AIDS, SARS, Covid-19

    Spread much faster bc air travel, trains, trucks (see AIDS in Africa, bubonic plague, SARS)

    Kinshasa "AIDS highway" https://en.wikipedia.org/wiki/Kinshasa_Highway

    Toxicology-chemical hazards

    Radon: 226 mass, stays in lower lobes of the lungs, found in basements where Uranium ores are present (Colorado, Alaska)

    Asbestos: fibrous non-burning insulating material, mined for ages as an insulator, tabletop, flooring, insulation. Fibers in the air cause asbestosis in the lungs, and various forms of lung cancer (carcinoma)

    lead: used in many manufacturing processes, batteries, plumbing/solder, gasoline (yes, gasoline as tetra ethyl lead), causes brain retardation (see romans and lead), replaced in gasoline by MTBE, which causes cancer.

    PBDE (polybrominated diphenyl ethers) fire retardants (e.g. TRIS), PBDEs are also hormone disrupters

    Risk vs. reward (see malaria and DDT)

    VOC in drinking water

    Heptachlor in green chop hawaii

    EDB in water on Oahu (ant poison)

    DDT-foggers in 1960’s….

    Toxins

    Carcinogens-cause cancer, long term or short term

    Mutagens-mutate you or your kids (reproductive DNA)

    Teratogens-cause birth defects: fetal alcohol syndrome (huge in Russia), thalidomide

    Neurotoxins-mercury and other heavy metals (Minamata Bay), many derived from insecticides

    Allergens-airborne or food borne

    Pathway inhibitors-endocrine disruptors, BPA, Phthalates (plastics)

    -----------

    Exposure: acute or chronic

    Polar concentration-air currents






    toxic concentration: DDT

    Bioaccumulation-A single creature

    Biomagnification-MANY trophic levels, MANY creatures



    Dose response analysis: determining the dose to have some sort of immediate impact, usually on test animals, but can also be part of a "natural experiment" where something happens to a human or other population, not planned, but well documented.

    LD50 and ED50 (not the same)

    LD50 is the dose that kills 50% of the population, so LD50 means "lethal dose to 50%"

    ED50 is the effective dose (ED) in a test, which can be good or bad: good might be aspirin, but usually it means amount to cause some non-lethal effect, like mice losing their hair.




    Threshold dose (non linear)

    Pesticide poisoning: Yaqui indians, PCB endocrine disruptors



    Synergistic effects

    Endocrine disruptors

    Risk probability

    perception vs. reality



    risk assessment

    innocent until proven guilty vs. precautionary principle



    Laws:

    TOSCA 1976

    REACH 2007



    POPs persistent organic pollutants



    Aldrin, Chlordane, DDT, Dieldrin, Dioxin, Endrin

    https://en.wikipedia.org/wiki/Gasoline#Tetraethyllead



    Comments

    /groups/apenvironmentalscience/search/index.rss?tag=hotlist/groups/apenvironmentalscience/search/?tag=hotWhat’s HotHotListHot!?tag=hot6/groups/apenvironmentalscience/sidebar/HotListadminadmin2013-02-05 02:24:03+00:002013-02-05 02:24:03updated4Added tag - hotadminadmin2013-02-05 02:24:02+00:002013-02-05 02:24:02addTag3adminadmin2013-02-05 02:05:35+00:002013-02-05 02:05:35updated2First createdadminadmin2013-02-05 02:03:35+00:002013-02-05 02:03:35created1wiki2013-02-05T02:24:03+00:00groups/apenvironmentalscience/wiki/394a8FalseEnergy notes/groups/apenvironmentalscience/wiki/394a8/Energy_notes.htmladmin4 updatesEnergy notes Week of 2.4.13: energy wrap-up e2 video: coal vs. nuclear in class AP exams: FRQ 2002.1 2004.2 2006.1 2007.2 2008.1 ...Falseadmin2013-02-05T02:24:03+00:00adminadmin2013-02-05 02:23:20+00:002013-02-05 02:23:20updated6Added tag - hotadminadmin2013-02-05 02:23:18+00:002013-02-05 02:23:18addTag5adminadmin2013-02-05 02:23:12+00:002013-02-05 02:23:12updated4adminadmin2013-02-05 02:21:48+00:002013-02-05 02:21:48updated3adminadmin2013-02-05 02:20:26+00:002013-02-05 02:20:26updated2First createdadminadmin2013-02-05 02:06:00+00:002013-02-05 02:06:00created1wiki2013-02-05T02:23:20+00:00groups/apenvironmentalscience/wiki/c360bFalseFeb-May plan/groups/apenvironmentalscience/wiki/c360b/FebMay_plan.htmladmin6 updatesFeb-May plan 1. conclusion of energy chapters (see previous wiki) 2. GCC AP questions FRQ: 2006.2 2005.3 2005.4 2007.3 ...Falseadmin2013-02-05T02:23:20+00:00adminadmin2012-03-07 05:53:55+00:002012-03-07 05:53:55updated14adminadmin2012-03-07 05:43:38+00:002012-03-07 05:43:38updated13adminadmin2012-03-07 05:41:35+00:002012-03-07 05:41:35updated12adminadmin2012-03-07 05:38:57+00:002012-03-07 05:38:57updated11Added tag - hotadminadmin2012-03-07 05:38:55+00:002012-03-07 05:38:55addTag10adminadmin2012-03-07 05:36:47+00:002012-03-07 05:36:47updated9adminadmin2012-03-07 05:22:26+00:002012-03-07 05:22:26updated8adminadmin2012-03-07 05:20:01+00:002012-03-07 05:20:01updated7adminadmin2012-03-07 05:18:58+00:002012-03-07 05:18:58updated6adminadmin2012-03-07 04:58:55+00:002012-03-07 04:58:55updated5adminadmin2012-03-07 04:57:33+00:002012-03-07 04:57:33updated4adminadmin2012-03-07 04:56:53+00:002012-03-07 04:56:53updated3adminadmin2012-03-07 04:54:20+00:002012-03-07 04:54:20updated2First createdadminadmin2012-03-07 04:53:33+00:002012-03-07 04:53:33created1weblog2012-03-07T05:53:55+00:00groups/apenvironmentalscience/weblog/de030FalseGreen Apple/groups/apenvironmentalscience/weblog/de030/Green_Apple.htmladmin14 updatesGreen Apple Team, Please watch this video about NYC: Trailer: http://www.pbs.org/e2/episodes/101_the_green_apple_trailer.html On the server: http://physics.hpa...Falseadmin2012-03-07T05:53:55+00:00adminadmin2011-09-13 19:08:24+00:002011-09-13 19:08:24updated4Added tag - hotadminadmin2011-09-13 19:08:22+00:002011-09-13 19:08:22addTag3adminadmin2011-09-13 19:08:10+00:002011-09-13 19:08:10updated2First createdadminadmin2011-09-13 19:04:30+00:002011-09-13 19:04:30created1weblog2011-09-13T19:08:24+00:00groups/apenvironmentalscience/weblog/4ecddFalseQuestions for Wednesday, wiki adds/groups/apenvironmentalscience/weblog/4ecdd/Questions_for_Wednesday_wiki_adds.htmladmin4 updatesQuestions for Wednesday, wiki adds Team, I'd like to try something for class tomorrow: each of you to create a question from chapter 3, and email it to me by this evening (Tuesday). Pl...Falseadmin2011-09-13T19:08:24+00:00adminadmin2011-09-08 21:36:21+00:002011-09-08 21:36:21updated29adminadmin2011-08-24 23:20:40+00:002011-08-24 23:20:40updated28adminadmin2011-08-24 22:42:36+00:002011-08-24 22:42:36updated27adminadmin2011-08-22 02:41:09+00:002011-08-22 02:41:09updated26adminadmin2011-08-22 02:40:02+00:002011-08-22 02:40:02updated25adminadmin2011-08-21 20:39:11+00:002011-08-21 20:39:11updated24adminadmin2011-08-21 20:30:42+00:002011-08-21 20:30:42updated23adminadmin2011-08-21 20:30:13+00:002011-08-21 20:30:13updated22adminadmin2011-08-21 20:25:48+00:002011-08-21 20:25:48updated21adminadmin2011-08-21 20:25:18+00:002011-08-21 20:25:18updated20adminadmin2011-08-21 00:22:12+00:002011-08-21 00:22:12updated19adminadmin2011-08-21 00:18:56+00:002011-08-21 00:18:56updated18adminadmin2011-08-21 00:15:43+00:002011-08-21 00:15:43updated17adminadmin2011-08-21 00:12:37+00:002011-08-21 00:12:37updated16adminadmin2011-08-21 00:12:02+00:002011-08-21 00:12:02updated15adminadmin2011-08-20 23:59:41+00:002011-08-20 23:59:41updated14Added tag - hotadminadmin2011-08-20 23:59:38+00:002011-08-20 23:59:38addTag13Added tag - conservationadminadmin2011-08-20 23:59:32+00:002011-08-20 23:59:32addTag12Added tag - critical thinkingadminadmin2011-08-20 23:59:19+00:002011-08-20 23:59:19addTag11Added tag - ch1adminadmin2011-08-20 23:59:08+00:002011-08-20 23:59:08addTag10Added tag - sustainabilityadminadmin2011-08-20 23:59:05+00:002011-08-20 23:59:05addTag9adminadmin2011-08-20 20:47:39+00:002011-08-20 20:47:39updated8adminadmin2011-08-20 20:46:15+00:002011-08-20 20:46:15updated7adminadmin2011-08-20 20:43:07+00:002011-08-20 20:43:07updated6adminadmin2011-08-20 19:14:13+00:002011-08-20 19:14:13updated5adminadmin2011-08-20 19:11:26+00:002011-08-20 19:11:26updated4adminadmin2011-08-20 18:59:57+00:002011-08-20 18:59:57updated3adminadmin2011-08-20 18:56:59+00:002011-08-20 18:56:59updated2First createdadminadmin2010-11-07 01:41:28+00:002010-11-07 01:41:28created1wiki2011-09-08T21:36:21+00:00groups/apenvironmentalscience/wiki/welcomeFalseCh01 Overview/groups/apenvironmentalscience/wiki/welcome/Ch01_Overview.htmladmin29 updatesCh01 Overview Welcome to our APES wiki. You should be able to do the following after logging in with your account: To create a new page, click the ...Falseadmin2011-09-08T21:36:21+00:00hot/groups/apenvironmentalscience/search/index.rss?sort=modifiedDate&kind=all&sortDirection=reverse&excludePages=wiki/welcomelist/groups/apenvironmentalscience/search/?sort=modifiedDate&kind=all&sortDirection=reverse&excludePages=wiki/welcomeRecent ChangesRecentChangesListUpdates?sort=modifiedDate&kind=all&sortDirection=reverse&excludePages=wiki/welcome0/groups/apenvironmentalscience/sidebar/RecentChangesListmodifiedDateallRecent ChangesRecentChangesListUpdateswiki/welcomeNo recent changes.reverse5searchlist/groups/apenvironmentalscience/calendar/Upcoming EventsUpcomingEventsListEvents1Getting events…